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Therapeutic Class Overview : New Avatars Of Microbes Super Bugs A Growing Threat Worldwide
Publication Date Feb 2014
Publisher MP ADVISORS
Product Type Report
Pages 12
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Novel approaches to treat infection is growing as the need is urgent! Misuse/overuse of antibiotics accelerated antimicrobial resistance (AMR) and has resulted in the emergence of “super bugs” which are posing life threatening challenges world wide. Many of the advances in medical treatment like cancer therapy; organ transplants etc. would go waste if the ability to fight infections during the treatment were not available. If that fails, the gains made in life-improving modern medical advantages will be lost creating a situation of - “one step forward two step back”.  Novel approaches are immediately required to combat these “super infections” warranting need for new classes of antibiotics and other preventive/therapeutic approaches.In this report We discuss -
The evolution and global dissemination of AMR
Unmet need in the critical setting esp. Gram Negative infections and CRE.
Pipeline of novel targets being used to develop new drugs to treat infections and resistance.
Pipeline of select drugs in mid and late clinical stage of development
Alarming Facts about AMR
Steps being taken by the regulatory authorities WW to address the issue and encourage novel therapeutics in this therapy area.
Developing Countries- /ROW -- Trends in pathogens and resistance
Role of diagnostics and preventive approach.

Table of Contents
Introduction- Evolution and global dissemination of Anti Micorbial Resistance (AMR)
How has the Problem Manifested tSuch an Alarming Level?
Microbial Evolution has Outpaced Innovation!-
Hitch Hiking and Globe Trotting by “Bad Bugs”-
Unmet need in the critical setting –
Running Out of Drugs tTreat Serious Gram-Negative Infections
Carbapenem-resistant Enterobacteriaceae (CREs)
Evolution of CRE -
Spreading the Bug
Need of the Hour- New Targets= New Antibiotic Class
Pipeline of novel targets being used tdevelop new drugs ttreat infections and
resistance.
Pipeline of select drugs in mid and late clinical stage of development
Alarming Facts about AMR - CDC Alerts
Action by Regulatory Bodies –tAccelerate Drug development and Threat Awareness-
US
The GAIN Act
Breakthrough Therapies Designation
Europe
Draft guidance “Expedited Programs for Serious Conditions––Drugs and Biologics”
Strategic Research Agenda
Developing Countries- /ROW -- Trends in pathogens and resistance
Role of diagnostics and preventive approach
List of Tables
Table 1 NEW TARGETS AND DRUGS FOR BAD BUGS
Table 2 LATE STAGE ANTI-INFECTIVE PIPELINE FOR SERIOUS HOSPITAL INFECTIONS
List of Figures
Figure 1. Global spread of the New Delhi metallo-beta lactamase encoding Ggene (NDM-1).

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